Professor Quan Zou: Breakthroughs in Multiple Sequence Alignment
Professor Quan Zou: Breakthroughs in Multiple Sequence Alignment
Professor Quan Zou's presentation focused on the multiple sequence alignment (MSA) technology of the SARS-CoV-2 virus. MSA is a key technique in bioinformatics that enables scientists to accurately identify viral mutation sites, calculate sequence distances, and analyze linkage disequilibrium. To address these challenges, Professor Zou's team proposed an innovative alignment method using efficient storage technologies such as trie trees, suffix trees, and suffix arrays, which significantly reduced computational time and space costs. The HAlign multiple sequence alignment system, developed by Professor Zou's team, leverages the MapReduce parallel mechanism to align one million high-quality SARS-CoV-2 genomes within just 30 minutes on a single-node server, demonstrating remarkable performance. This achievement not only provides a powerful tool for virology research but also injects new vitality into the development of bioinformatics.
