Research

郭晶晶 Guo Jingjing

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 Biography

Dr. Jingjing Guo is a professor in Macao Polytechnic University. She graduated from Lanzhou University with Ph.D. degree in medicinal chemistry in 2015. She has made a series of innovative achievements in protein structure and function, membrane response to organic small molecules, etc. She has published more than 40 SCI papers, including Chemical Reviews, Elife and other international authoritative journals.

 Education and Experiences

Educational background
2009-2015: Ph.D. in Medicinal Chemistry, Lanzhou University, China
2013-2015: Visiting Ph.D. student in Biophysics, Florida State University, United States
2005-2009: B.S. in Chemistry, Hebei Normal University, China

Working experience
2022-present: Professor, Macao Polytechnic University
2019-2022: Professor, Nanjing Agricultural University, China
2017-2019: Research Fellow, Nanyang Technological University, Singapore
2015-2018: Associate Professor, Henan Normal University, China

 Research Interests

Computational structural biology and computer-aided drug/agrichemical design

• Structure-based or AI-powered drug/agrichemical design
• Allosteric regulation mechanisms and the rational design of enzymes
• Molecular basis for the function of membranes

 Selected Publications

1. Protein Allostery:

• Guo, J.; Zhou, H.-X., Protein allostery and conformational dynamics. Chem. Rev. 2016, 116 (11), 6503-15.

GPCRs:

• M. Li; Y. Bao; M. Li; J. Guo*, GPCR Allostery: a View from Computational Biology. Current Medicinal Chemistry, 2023, Accept
• Li, M.; Li, M.; Guo, J.*, Molecular Mechanism of Ca(2+) in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1. J. Chem. Inf. Model. 2022, 62, 5110.
• M. Li; Y. Bao; R. Xu; M. Li; L. Xi; J. Guo*, Understanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator. Cells, 2023, 12, 41.
• M. Li; Y. Bao; R. Xu; X. Zhang; H. La; J. Guo*, Mechanism of enhanced sensitivity of mutated beta-adrenergic-like octopamine receptor to amitraz in honeybee Apis mellifera: An insight from MD simulations. Pest Manag Sci, 2022, 78, 5423.

Enzymes:

• Zhong, W.^#;  Guo, J. ^#;  Cui, L.^#; Chionh, Y. H.; Li, K.;  El Sahili, A.; Cai, Q.;  Yuan, M.; Michels, P. A. M.; Fothergill-Gilmore, L. A.; Walkinshaw, M. D.; Mu, Y.;  Lescar, J.; Dedon, P. C., Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in Mycobacterium tuberculosis. J. Mol. Biol. 2019, 431 (19), 3690-3705. (Co-first author)
• Guo, J.; Zhou, H. X., Allosteric activation of SENP1 by SUMO1 beta-grasp domain involves a dock-and-coalesce mechanism. Elife 2016, 5, e18249.
• Guo, J.; Pang, X.; Zhou, H.-X., Two pathways mediate interdomain allosteric regulation in pin1. Structure 2015, 23 (1), 237-47.

2. Biological membrane structure & function:

• P. Xin*; L. Xu; W. Dong; L. Mao; J. Guo*; J. Bi; S. Zhang; Y. Pei; C. P. Chen*, Synthetic K⁺ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System. Angew Chem Int Ed Engl, 2023. https://doi.org/10.1002/anie.202217859
• Bao, Y.;  Li, M.;  Xie, Y.; Guo, J.*, Investigating the Permeation Mechanism of Typical Phthalic Acid Esters (PAEs) and Membrane Response Using Molecular Dynamics Simulations. Membranes 2022, 12 (6), 596.
• Guo, J.; Chia, G. W. N.;  Berezhnoy, N. V.;  Cazenave-Gassiot, A.;  Kjelleberg, S.;  Hinks, J.; Mu, Y.; Seviour, T., Bacterial lipopolysaccharide core structures mediate effects of butanol ingress. BBA-Biomembranes 2020, 1862 (2), 183150.
• Guo, J.;  Ho, J. C. S.;  Chin, H.;  Mark, A. E.;  Zhou, C.;  Kjelleberg, S.;  Liedberg, B.;  Parikh, A. N.;  Cho, N. J.;  Hinks, J.;  Mu, Y.; Seviour, T., Response of microbial membranes to butanol: interdigitation vs. disorder. Phys. Chem. Chem. Phys. 2019, 21 (22), 11903-11915.