郭晶晶 Guo Jingjing
Guo Jingjing
Professor
Tel: (853) 8599 6895
Email: jguo@mpu.edu.mo
Scopus | Google Scholar | ResearchGate
Biography
Dr. Jingjing Guo joined the Center for Artificial Intelligence Driven Drug Discovery (AIDD) at Macao Polytechnic University as a professor in 2022. She has made a series of innovative achievements in computational biology and drug discovery. Now she has published more than 70 SCIE papers, including Chemical Reviews, Elife, Angewandte Chemie International Edition, WIREs Computational Molecular Science, and other international authoritative journals. She has served as Associate Editor of Current Research in Structural Biology since January 2024.
https://research.mpu.edu.mo/en/persons/jingjing-guo
Education and Experiences
Educational background
2009-2015: Ph.D. in Medicinal Chemistry, Lanzhou University, China
2013-2015: Visiting Ph.D. student in Biophysics, Florida State University, United States
2005-2009: B.S. in Chemistry, Hebei Normal University, China
Working experience
2022-present: Professor, Macao Polytechnic University
2019-2022: Professor, Nanjing Agricultural University, China
2017-2019: Research Fellow, Nanyang Technological University, Singapore
2015-2018: Associate Professor, Henan Normal University, China
Research Interests
Computational structural biology and computer-aided drug/agrichemical design
- Structure-based or AI-powered drug/agrichemical design
- Allosteric regulation mechanisms and the rational design of enzymes
- Molecular basis for the function of membranes
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Artificial intelligence and healthcare big data
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AI-empowered drug repositioning and drug discovery
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AI-driven protein design and modification
Selected Publications
- Shi, L.; Zhao, W.; Jiu, Z.; Guo, J.*; Zhu, Q.; Sun, Y.; Zhu, B.; Chang, J.; Xin, P.* Redox-Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion-Permeation Pathway. (Angew Chem Int Ed Engl, IF=16.823), 2024, e202403667.
- Bao, Y.; Jia, F.; Li, M.; Xu, R.; Xie, Y.; Zhang, F.*; Guo, J.* Characterizing the Molecular Mechanism of the Lethal C423D Mutation in FgMyoI: A Molecular Perspective. (J Agric Food Chem, IF=6.1) 2024, 72, 1539-1549.
- J. Guo*; Y. Bao; M. Li; S. Li; L. Xi; P. Xin; L. Wu; H. Liu; Y. Mu, Application of computational approaches in biomembranes: From structure to function. (WIREs Computational Molecular Science, IF=11.5), 2023, e1679.
- L. Xi; A. Shi; T. Shen; G. Wang; Y. Wei*; J. Guo*, Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies. (Frontiers in Pharmacology, IF=5.988), 2023, 14, 1197856.
- P. Xin*; L. Xu; W. Dong; L. Mao; J. Guo*; J. Bi; S. Zhang; Y. Pei; C. P. Chen*, Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System. (Angew Chem Int Ed Engl, IF=16.823), 2023, 62, e202217859.
- M. Li; Y. Bao; R. Xu; M. Li; L. Xi; J. Guo*, Understanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator. (Cells, IF=7.666), 2023, 12.
- M. Li; M. Li; J. Guo*, Molecular Mechanism of Ca2+in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1. (Journal of Chemical Information and Modeling, IF=6.162), 2022, 62, 5110.
- J. Guo; H. X. Zhou, Protein Allostery and Conformational Dynamics. (Chemical Reviews, IF=72.087), 2016, 116, 6503.
- J. Guo; H. X. Zhou, Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism. (eLife, IF=8.713), 2016, 5.
- J. Guo; X. Pang; H. X. Zhou, Two pathways mediate interdomain allosteric regulation in Pin1. (Structure, IF=5.871), 2015, 23, 237.